This Funding Opportunity Announcement (FOA) is soliciting applications to support existing cohorts to address how pre-, peri-, and post-natal environmental exposures impact childhood development and health outcomes as part of the Environmental influences on Child Health Outcomes (ECHO) program.

Increasing

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evidence suggests that exposures early in life (e.g.

nicotine, diet, microbiome) can result in health deficits and lead to life-long consequences.

The purpose of this FOA is to leverage and build upon existing cohort infrastructure to prospectively investigate the role of early life exposures and underlying biological mechanisms in childhood health and disease.

This FOA runs in parallel with companion FOAs that solicit applications for the Coordinating Center (RFA-OD-16-006), Data Analysis Center (RFA-OD-16-005), Patient/Person Reported Outcomes Core (RFA-OD-16-003), Administrative Supplements to the Children's Health Exposure Analysis Resource (PA-16-046), IDeA States Pediatric Clinical Trials Network (RFA-OD-16-002 and RFA-OD-16-001), and a Genetics Core to be released in FY1 7. Funding for an exploratory UG3 phase will be used for planning, feasibility testing, and developing study documents, including the study protocol and Manual of Procedures.

UG3 projects that have met milestones will be administratively considered for transition to the UH3 implementation phase.

Applicants responding to this FOA must address objectives for both the UG3 and UH3 phases.