Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS)
Birth defects affect about three percent of all births in the United States and are a leading cause of infant mortality, morbidity, and healthcare costs.
Birth defects account for one in five infant deaths and contribute substantially to long-term disability.
Although some causes of birth defects have been identified (e.g., genetics, medications, and environmental exposures), the causes of two-thirds of birth defects remain unknown.
In 1996 Congress appropriated funds to develop the Centers for Birth Defects Research and Prevention (CBDRP).
Beginning that fiscal year, CDC awarded cooperative agreements to up to 9 different centers.
The two major collaborative activities of the centers have been case-control studies called the National Birth Defects Prevention Study (NBDPS), which collected data for deliveries between 1997 and 2011, and the Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS), which began collecting data for deliveries in 2014 and is ongoing through 202 3. To support research assessing risk factors for stillbirths (fetal deaths at 20 or more weeks gestation), a largely understudied pregnancy outcome, a case-control study of risk factors for stillbirth was added to BD-STEPS in 201 5. This notice of funding opportunity will continue to support the capacity of BD-STEPS to identify novel epidemiologic and genetic risk factors for major, structural birth defects and for stillbirths, and to provide research findings that are intended to be translated into public health prevention messages, as warranted.
Component A (BD-STEPS Core):
Support the epidemiological and genetic birth defect-related research capabilities of BD-STEPS, with a focus on studying:
(1) maternal chronic diseases and their treatments; (2) infectious disease in pregnancy; and (3) medications used during pregnancy.
Component B (BD-STEPS Stillbirth):
Support the exploration of modifiable risk factors for stillbirths.
Component B recipients must apply for and receive concurrent Component A funding.
New applicants and current BD-STEPS recipients are encouraged to apply for both components.
Birth defects account for one in five infant deaths and contribute substantially to long-term disability.
Although some causes of birth defects have been identified (e.g., genetics, medications, and environmental exposures), the causes of two-thirds of birth defects remain unknown.
In 1996 Congress appropriated funds to develop the Centers for Birth Defects Research and Prevention (CBDRP).
Beginning that fiscal year, CDC awarded cooperative agreements to up to 9 different centers.
The two major collaborative activities of the centers have been case-control studies called the National Birth Defects Prevention Study (NBDPS), which collected data for deliveries between 1997 and 2011, and the Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS), which began collecting data for deliveries in 2014 and is ongoing through 202 3. To support research assessing risk factors for stillbirths (fetal deaths at 20 or more weeks gestation), a largely understudied pregnancy outcome, a case-control study of risk factors for stillbirth was added to BD-STEPS in 201 5. This notice of funding opportunity will continue to support the capacity of BD-STEPS to identify novel epidemiologic and genetic risk factors for major, structural birth defects and for stillbirths, and to provide research findings that are intended to be translated into public health prevention messages, as warranted.
Component A (BD-STEPS Core):
Support the epidemiological and genetic birth defect-related research capabilities of BD-STEPS, with a focus on studying:
(1) maternal chronic diseases and their treatments; (2) infectious disease in pregnancy; and (3) medications used during pregnancy.
Component B (BD-STEPS Stillbirth):
Support the exploration of modifiable risk factors for stillbirths.
Component B recipients must apply for and receive concurrent Component A funding.
New applicants and current BD-STEPS recipients are encouraged to apply for both components.
Related Programs
Birth Defects and Developmental Disabilities - Prevention and Surveillance
Department of Health and Human Services
Agency: Department of Health and Human Services
Office: Centers for Disease Control and Prevention - ERA
Estimated Funding: $20,650,000
Office: Centers for Disease Control and Prevention - ERA
Estimated Funding: $20,650,000
Who's Eligible
Relevant Nonprofit Program Categories
Obtain Full Opportunity Text:
Alaska Native-Serving and Native Hawaiian-Serving Institutions Education Competitive Grants Program (ANNH)
Additional Information of Eligibility:
For an application to be considered, it must be responsive to the following information.
If it is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process.
HHS/CDC will notify the applicant that the application did not meet the submission requirement.
Both Components A and B should have: A selected birth population and geographic study area that includes between 30,000 - 80,000 births annually.
Access to state National Electronic Disease Surveillance Systems (NEDSS) for ascertainment of reportable infections is required.
Legal authority to share identifiable, individual-level data with CDC and other recipients.
Component A Core should also have: Legal access to a pre-existing, population-based, active birth defects surveillance system.
Legal access to data sources to ascertain liveborn control infants.
A funding amount request that is less than the ceiling of $800,000 (for Component A) as indicated in Section II.
Award Information.
Component B Stillbirths should also have: Legal access to data sources to ascertain stillbirths.
Documentation of component A application (copy of face page).
A funding amount request that is less than the ceiling of $350,000 (for Component B) as indicated in Section II.
Award Information.
Full Opportunity Web Address:
http://nifa.usda.gov/funding/rfas/alaska.html
Contact:
Agency Email Description:
uxl8@cdc.gov
Agency Email:
Date Posted:
2022-11-01
Application Due Date:
Archive Date:
2023-02-09
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